All depends on the wheel size.
I run 18x10 rear wheels on an R33 GTSt with 265/35 rubber, and i've got my coilovers wound....pretty much all the way down, there's still some more left, but i don't want to go lower. My tyres are tucked up inside the guards.
My main issue was with the 9" wide fronts when on full lock coming up gutters. Sorted that out, by getting the guards rolled. ALl good now.