Diagnostic flow for a code 21 says check signal at the ECU pins, on a voltmeter of some kind it should read 0.1V at idle, 0.12V cranking, 0.15-0.25V at 2000 rpm. Check each coil such that +1, -3 is infinite or very high resistance, -3, +2 should do the same. (-1, +3), (+3, -2), (+1, -2), and (-1, +2) should all be somewhere between 0 ohms and high resistance. If you trace the path from the coil pin all the way back to the ECU in the diagram the resistance you measure at the coil vs connected to the harness should be pretty much the same.