itbmils,
You need to take some timing out. By the sounds of it the tune was aiming at getting you lots of power. The problem is it can leave very little margin for changes in air quality and temperatures resulting in higher than you want knock values.
The normal driving knock under light throttle / cruising might be a buggered O2 sensor. We found mine were stuffed when we were tuning mine in 'closed loop' so for the time being I have it turned off and will suffer the slightly worse fuel ecconomy, for the sake of safety. Mind you the fuel ecconomy was crap as a result anyway, so it might even improve.