do not run power cables with rca's or speaker cables, use oxgen free copper for all cables running to and from the amp, use all gold plated connetions all connetions to be solder as well. As for speaker lay out, subbs to be facing windows eg back window. splits to be facing the centre of the car say just above the centre console, if you have 6x9's dont run them of the amp they will conflict with the sub noise they are to be used as rear fill only.
Good luck thats about all i can give you.
oh amp cable should be 10g which is 10 gauge oxgen free power cables.