yeah - you'd have to cc everything and then work out how much to take off the head to get the comp your after.
Higher comp gives better off boost respose, better fuel economy and if your tuner is good ( I know your tuning it - so no offense implied ) you should be able to make good power on lower boost.
Mine has no detonation at 18psi on 100 Shel V power, and Im hoping to run 22 plus psi.