I have no idea on hybrids. Rule of thumb, more complex = more maintenance cost. Some hybrid parts are not serviceable unless by the dealership. For the time being I'd personally stay away from hybrids - unless she just plans on keeping the car for 2 to 3 years and turning over to another one.
Lexus, is an excellent choice IMO. I have a '99 IS200 regularly maintained approaching 190,000. Still going strong, still tight and no rattles or squeaks - not a single fault....
My car and the latest model Lexus still feel very "Toyota", ie switchgear. it feels like a blinged out Corolla with leather. I'm not questioning the quality - It just doesn't feel exclusive/premium especially when you can see switch gear directly out of an Echo, Corolla and Camry.
The big advantage with a Lexus is parts are interchangeable with it's much cheaper Toyota siblings - So parts are plentiful and reasonably priced, most people that have worked with a Corolla and Camry would have little issues with servicing a Lexus since the there are so many similarities.
If she isn't too fussed I'd say get a 2nd hand IS250 - Lots of goodies at a reasonable price and they tend to hold their value better.