howstuff works or google on how to read compressor maps. work out how much airflow you need to make your power target and then simply pick a compressor wheel combo that suits that output and its efficency should be spot on. takes out the guess work.
well you can get a big single, one amount of rotating mass, interia, friction
also oil, water, ball bearing
or
two smaller twins, two amonuts of rotating mass, twice the interia needed, twice as much friction and heat loss. you wouldnt want plain bearing twins as it would preform worse than a ball bearing single
i dont see how a large single vs twins would vary much in terms of lag.
as long as you did your homework on the compressor maps and made sure it was spot on, i dont see how it would be more or less laggy, if anything i could only see big single as being better