it is related. timing, efficiency etc have no effect on the injector duty itself.
regardless of duty the amount of times it fires per minute is only affected by engine rpm. inj duty is the % of time the injector is open in every pulse, ie at 0% it never opens, at 50% its open for the same amount of time as it is closed, so half the time, at 100% its constantly open.
its not exact but yes in 4th you would be using around 20% less fuel than you would be in 3rd in your example