Yes it will
Factory pistons can only handle so much combustion pressure, same with rods, bearings etc. these motors are nearly 20 year old and most will have over 200,000ks so getting near rebuild time at factory power levels, and well past it when they are making double the factory power.
Sure you could build a 1000hp rb25DE run it once on the dyno for a number and then never go past 3000rpm ever again and it will last quite a while.
But what is the point in that?