I think this comment makes a lot of sense.
If you listening for knock and you are getting slightly uneven distribution, then the cylinder that isn't getting as much injected into it will ping before the others. As soon as you can hear the engine ping, back the timing off for safety and there shouldn't be any problems.
Having said that, I'm not an expert by any stretch. Most people seem to have no dramas with just one nozzle though... I think like it was mentioned it would be less of a problem with the stock intake on a rb25 compared with a forward facing plenum.